Lymfactin® for lymphedema

Lymphedema means chronic, progressive swelling of affected tissues. Approximately 20% of breast cancer patients who undergo axillary lymph node dissection get secondary lymphedema, a disabling and disfiguring condition that severely affects quality of life. There is no cure.

herantis_image_04Over 200,000 patients in the USA and Europe are estimated to live with breast-cancer associated lymphedema, with an estimated 30,000 new patients developing the complication each year. Secondary lymphedema is currently treated e.g. with compression garments, special massage, and exercises. While these therapies may relief the symptoms they do not cure the condition, which is caused by damage to the lymph system.

Herantis’ Lymfactin® aims at recovering the damaged lymph system by reconstituting lymphatic vasculature. Preclinical pharmacology studies in lymphedema models have confirmed the effects of Lymfactin® on growth of new functional lymphatic vessels and functional improvement of lymphatic flow.

herantis_image_06Clinical development

Herantis has launched a phase I clinical study to be conducted at 3 European clinical sites, in women with breast cancer associated secondary lymphedema. While the primary endpoint of the study is to assess the safety and tolerability of Lymfactin® the study will also assess the preliminary efficacy of the treatment. The study intends to recruit at most 21 patients at three University hospitals in Finland (in Helsinki, Tampere, and Turku) and recruitment is expected to be completed in 2017.

Patients who have breast cancer associated lymphedema and who are interested in the clinical study are referred to their nearest participating University Hospital in Finland:


  • Tampere University Hospital / PSHP: Study nurse Seija Rautiainen, Seija.Rautiainen (at)
  • Turku University Hospital / VSSHP: Study nurse Kirsi Penttilä, Kirsi.Penttila (at)
  • Helsinki University Hospital / HUS: Study nurse Kira Olenius, Kira.Olenius (at)

Patient support and Lymphedema awareness

Herantis is a member of the non-profit organisation LE&RN (Lymphatic Education & Research Network) whose vision is a world without Lymphedema. Please sign their petition to World Health Organisation WHO on Lymphedema awareness. The petition site also includes a video where Hollywood actress Kathy Bates and others why this is important. Direct link to the petition and video: