Herantis Pharma announces first healthy volunteer dosed in the Phase 1a clinical study for the Parkinson’s disease drug candidate, HER-096

Herantis Pharma Plc, Press release, 19 April 2023 at 11 a.m. EEST

The Phase 1a clinical study will assess safety, tolerability, and blood-brain barrier penetration of subcutaneously administered HER-096.

Herantis Pharma Plc ("Herantis"), a company developing disease-modifying therapies for Parkinson’s disease, is pleased to announce the dosing of the first healthy volunteer in the Phase 1a clinical study for HER-096.

“We are excited to start the Phase 1a clinical study with HER-096. This is an important milestone on our way towards developing a disease-modifying therapy for slowing or stopping the progression of Parkinson’s disease which is a major unmet clinical need today,” said Antti Vuolanto, the CEO of Herantis Pharma. “We expect to obtain the topline data by the end of 2023. If the results are in line with our expectations, we will move on to study HER-096 in Parkinson's patients.”

The study takes place in Turku, Finland conducted by the contract research organization, CRST.

About the HER-096 Phase 1a clinical study:

The study is a randomized, double-blinded, placebo-controlled, safety, tolerability, and pharmacokinetic study of subcutaneous single ascending doses of HER-096. The study aims to recruit around 60 healthy volunteer subjects. More information about the study and participation into the study can be found on the website (only in Finnish): https://osallistulaaketutkimukseen.fi/kliininen-laaketutkimus-20-45-vuotiaille-miehille-c739/

About HER-096

HER-096 is a peptidomimetic molecule designed to retain the biological activity of the neuroprotective CDNF protein. HER-096 has demonstrated to have a multimodal mechanism of action mimicking CDNF and to improve functional recovery of damaged neurons in preclinical models. Importantly, HER-096 has been shown to readily penetrate the blood-brain barrier in preclinical studies allowing convenient subcutaneous dosing. Thanks to its multimodal mechanism of action, Herantis’ HER-096 has the potential to stop the progression of Parkinson’s disease and significantly improve patients’ quality of life.

For more information, please contact:

Julie Silber/Gabriela Urquilla

Tel: +46 (0)7 93 486 277/+46 (0)72-396 72 19

Email: ir@herantis.com

Certified Advisor: UB Securities Ltd, Finland: +358 9 25 380 225

Company website: www.herantis.com

About Herantis Pharma Plc

Herantis Pharma Plc is an innovative biotech company developing disease modifying therapies for Parkinson’s disease. Herantis’ lead product HER-096, is an advanced small synthetic chemical peptidomimetic molecule developed based on the active site of the parent CDNF protein. It combines the compelling mechanism of action of the CDNF protein with the convenience of subcutaneous administration. The shares of Herantis are listed on the Nasdaq First North Growth Market Finland.

For more information, please visit www.herantis.com.

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