Tieteelliset julkaisut

CDNF-hermokasvutekijäperhe

2021
Sjögren M, Huttunen HJ, Svenningsson P, Widner H. Genetically Targeted Clinical Trials in Parkinson’s Disease: Learning from the Successes Made in Oncology. Genes 12(10): 1529, 2021.
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2021
Huttunen HJ, Booms S, Sjögren M, Cryar A, Harris J, Sirka E. Dove M, Majbour NK, Abdesselem HB, El-Agnaf OM, Koskinen J, Holmnäs R, Kerstens V, Johansson J, Rinne J, Varrone A, Wolley M, Murphy B, Fielder P, Baker J, Skinner P, Andréasson M, Paul-Visse G, Kivisaari R, Bjartmarz H, Lind G, Almqvist P, Scheperjans F, Widner H, Svenningsson P. First-in-Man Clinical Trial of Intraputamenal CDNF in Parkinson’s Disease Finds a Consorted Biomarker Response in a Subgroup of Subjects. [MDS 2021 POSTER]
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2021
Huttunen HJ, Booms S, Kerstens V, Fazio P, Johansson J, Koskinen J, Sjögren M, Saarma M, Woolley M, Murphy B, Fielder P, Baker J, Skinner P, Andreasson M, Paul-Visee G, Kivisaari R, Bjartmarz H, Lind G, Almqvist P, Rinne J, Varrone A, Scheperjans F, Widner H, Svenningsson P. Phase I-II First-In-Man Clinical Trial Of Intraputamenal CDNF in Parkinson’s Disease: Topline Results Of The 12-Month Treatment Period. [AD/PD™ 2021 ABSTRACT]
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2021
Huttunen HJ, Booms S, Majbour NK, Abdesselem HB, El-Agnaf OM, Poggiolini I, Parkkinen L, Cryar A, Harris J, Sirka E, Dove M, Sjögren M, Woolley M, Murphy B, Fielder P, Baker J, Skinner P, Andreasson M, Paul-Visee G, Kivisaari R, Bjartmarz H, Lind G, Almqvist P, Scheperjans F, Widner H, Svenningsson P. Phase I-II First-In-Man Clinical Trial of Intraputamenal CDNF in Parkinson’s Disease: Exploratory Fluid-Based Biomarker Endpoints of The 12-Month Treatment Period. [AD/PD™ 2021 ABSTRACT]
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2020
Stepanova P, Srinivasan V, Lindholm D, Voutilainen MH. Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington's disease. Sci. Rep. 10(1): 19045, 2020.
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2020
Chalazonitis A, Li Z, Pham TD, Chen J, Rao M, Lindholm P, Saarma M, Lindahl M, Gershon MD. Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit. J Comp. Neurol. 528(14): 2420-2444, 2020.
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2020
Chen YC, Baronio D, Semenova S, Abdurakhmanova S, Panula P. Cerebral Dopamine Neurotrophic Factor Regulates Multiple Neuronal Subtypes and Behavior. J. Neurosci. 40(32): 6146-6164, 2020.
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2020
Lindahl M, Chalazonitis A, Palm E, Pakarinen E, Danilova T, Pham TD, Setlik W, Rao M, Võikar V, Huotari J, Kopra J, Andressoo JO, Piepponen PT, Airavaara M, Panhelainen A, Gershon MD, Saarma M. Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiol. Dis. 134: 104696, 2020.
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2019
Huttunen HJ, Saarma M. CDNF Protein Therapy in Parkinson's Disease. Cell Transplant. Apr 4:963689719840290, 2019.
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2019
Sousa-Victor P, Neves J, Cedron-Craft W, Britten Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA and Jasper H. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nat. Metab. 1: 276-290, 2019.
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2019
Yan Y, Rato C, Rohland L, Preissler S, Ron D. MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat. Commun. 10(1): 541, 2019.
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2018
Huotarinen A, Penttinen AM, Bäck S, Voutilainen MH, Julku U, Petteri Piepponen T, Männistö PT, Saarma M, Tuominen R, Laakso A, Airavaara M. Combination of CDNF and deep brain stimulation decreases neurological deficits in late-stage model Parkinson's disease. Neuroscience epub Feb 3 2018. pii: S0306-4522(18)30082-4.
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2018
Mätlik K, Anttila JE, Kuan-Yin T, Smolander OP, Pakarinen E, Lehtonen L, Abo-Ramadan U, Lindholm P, Zheng C, Harvey B, Arumäe U, Lindahl M, Airavaara M. Poststroke delivery of MANF promotes functional recovery in rats. Sci. Adv. 4(5): eaap8957, 2018
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2018
Renko JM, Bäck S, Voutilainen MH, Piepponen TP, Reenilä I, Saarma M, Tuominen RK. Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats. Mol. Neurobiol. epub Jan 18 2018. doi: 10.1007/s12035-018-0872-8.
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2018
Sousa-Victor P, Jasper H, Neves J. Trophic Factors in Inflammation and Regeneration: The Role of MANF and CDNF. Front. Physiol. 9:1629, 2018.
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2018
Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M. MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Mol. Ther. 26(1): 238-255, 2018.
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2017
Yang S, Yang H, Chang R, Yin P, Yang Y, Yang W, Huang S, Gaertig MA, Li S, Li XJ. MANF regulates hypothalamic control of food intake and body weight. Nat. Commun. 8(1): 579, 2017.
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2017
Gao FJ, Wu JH, Li TT, Du SS, Wu Q. Identification of Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Novel Neuroprotective Factor for Retinal Ganglion Cells. Front. Mol. Neurosci. 10: 76, 2017.
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2017
Lindahl M, Saarma M, Lindholm P. Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential. Neurobiol. Dis. 97(Pt B): 90-102, 2017.
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2017
Lindström R, Lindholm P, Palgi M, Saarma M, Heino TI. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. BMC Genet. 18(1): 52, 2017.
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2017
Mätlik K, Vihinen H, Bienemann A, Palgi J, Voutilainen MH, Booms S, Lindahl M, Jokitalo E, Saarma M, Huttunen HJ, Airavaara M, Arumäe U. Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro 4(1) pii: ENEURO.0128-16.2017, 2017.
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2017
Tang T, Li Y, Jiao Q, Du X, Jiang H. Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease. Neurosci. Bull. 33(5): 568-575, 2017.
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2017
Voutilainen MH, De Lorenzo F, Stepanova P, Bäck S, Yu LY, Lindholm P, Pörsti E, Saarma M, Männistö PT, Tuominen RK. Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action. eNeuro 4(1). pii: ENEURO.0117-16.2017, 2017.
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2017
Wang L, Wang Z, Zhu R, Bi J, Feng X, Liu W, Wu J, Zhang H, Wu H, Kong W, Yu B, Yu X. Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression. PLoS One 12(6): e0179476, 2017.
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2016
Garea-Rodríguez E, Eesmaa A, Lindholm P, Schlumbohm C, König J, Meller B, Krieglstein K, Helms G, Saarma M, Fuchs E. Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease. PLoS ONE 11(2): e0149776, 2016.
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2016
Neves J, Zhu J, Sousa-Victor P, Konjikusic M, Riley R, Chew S, Qi Y, Jasper H, Lamba DA. Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science 353(6294):aaf3646, 2016.
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2016
Zhao H, Cheng L, Du X, Hou Y, Liu Y, Cui Z, Nie L. Transplantation of Cerebral Dopamine Neurotrophic Factor Transducted BMSCs in Contusion Spinal Cord Injury of Rats: Promotion of Nerve Regeneration by Alleviating Neuroinflammation. Mol. Neurobiol. 53(1): 187-99, 2016.
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2016
Lindström R, Lindholm P, Kallijärvi J, Palgi M, Saarma M, Heino TI. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS ONE 11(3): e0151550, 2016.
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2015
Kemppainen S, Lindholm P, Galli E, Lahtinen HM, Koivisto H, Hämäläinen E, Saarma M, Tanila H. Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. Behav Brain Res. 291: 1-11, 2015.
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2015
Latge C, Cabral KM, de Oliveira GA, Raymundo DP, Freitas JA, Johanson L, Romão LF, Palhano FL, Herrmann T, Almeida MS, Foguel D. The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers. J. Biol. Chem. 290(33): 20527-40, 2015.
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2015
Mätlik K, Yu LY, Eesmaa A, Hellman M, Lindholm P, Peränen J, Galli E, Anttila J, Saarma M, Permi P, Airavaara M, Arumäe U. Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity. Cell Death Dis. 6: e2032, 2015.
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2015
Voutilainen MH, Arumäe U, Airavaara M, Saarma M. Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease. FEBS Lett. 589:3739-48, 2015.
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2014
Lindahl M, Danilova T, Palm E, Lindholm P, Võikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M. MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells. Cell Rep. 7: 366-75, 2014.
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2014
Yang S, Huang S, Gaertig MA, Li XJ, Li S. Age-dependent decrease in chaperone activity impairs MANFexpression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron 81(2): 349-65, 2014.
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2012
Airavaara M, Harvey BK, Voutilainen MH, Shen H, Chou J, Lindholm P, Lindahl M, Tuominen RK, Saarma M, Hoffer B, Wang Y. CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice. Cell Transplant. 21: 1213-23, 2012.
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2011
Voutilainen MH, Bäck S, Peränen J, Lindholm P, Raasmaja A, Männistö PT, Saarma M, Tuominen RK. Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease. Exp. Neurol. 228: 99-108, 2011.
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