Scientific publications

Kulesskaya, Natalia; Holmström, Kira M.; Huttunen, Henri J. Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease.

Kira M. Holmström, Katarina Jääskeläinen, Natalia Kulesskaya, Jani Koskinen, Päivi Vuorio, Antti Vuolanto, Marica T. Engström, Mika Scheinin, Charlotte Videbaek, Aleksi Tornio & Henri J. Huttunen. A Phase 1a first-in-human clinical trial of HER-096, a subcutaneously administered cdnf-derived peptidomimetic.

Natalia Kulesskaya, Kira M. Holmström and Henri J. Huttunen. Exploring the multiple mechanisms underlying HER-096 neuroprotection and regeneration.

Natalia Kulesskaya, Arnab Bhattacharjee , Kira M. Holmström , Päivi Vuorio , Alexandre Henriques , Noëlle Callizot , Henri J. Huttunen. HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson’s disease

Natalia Kulesskaya, Arnab Bhattacharjee, Kira M. Holmström, Rebecka Holmnäs, Jani Koskinen, Satu Leikas, Sigrid Booms, Antti Vuolanto & Henri J. Huttunen. HER-096 Is a Novel Brain-Penetrating Peptidomimetic That Promotes Proteostasis and Reduces Neuroinflammation in an Aged Mouse Model of Synucleinopathy [AD/PD™ 2023 POSTER]

Huttunen et al. Structural basis of CDNF interaction with the UPR regulator GRP78. Nature Communications (2024)15:8175

Huttunen et al. Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial. Mov. Disord. epub May 22, 2023.

De Lorenzo et al. CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. Brain 16: awad087, 2023.

Tseng et al. Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage. Cell Death Dis. 14(2): 128, 2023.

Eesmaa et al. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int. J. Mol. Sci. 23(16): 9489, 2022.

Lindholm and Saarma. Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism. Mol. Psych.. 27(3): 1310-1321, 2022.

Albert et al. Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo. Mol. Ther. 29(9): 2821-2840, 2021.

Chalazonitis A, Li Z, Pham TD, Chen J, Rao M, Lindholm P, Saarma M, Lindahl M, Gershon MD. Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit. J Comp. Neurol. 528(14): 2420-2444, 2020.

Lindahl M, Chalazonitis A, Palm E, Pakarinen E, Danilova T, Pham TD, Setlik W, Rao M, Võikar V, Huotari J, Kopra J, Andressoo JO, Piepponen PT, Airavaara M, Panhelainen A, Gershon MD, Saarma M. Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiol. Dis. 134: 104696, 2020.

Huttunen and Saarma. CDNF Protein Therapy in Parkinson's Disease. Cell Transplant. Apr 4:963689719840290, 2019.

Sousa-Victor P, Jasper H, Neves J. Trophic Factors in Inflammation and Regeneration: The Role of MANF and CDNF. Front. Physiol. 9:1629, 2018.

Lindholm, P Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 448: 73-77, 2007.